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ERRα antagonist-1

CAS No. 1072145-33-5

ERRα antagonist-1( ERR+/- antagonist-1 | ERRa antagonist-1 )

Catalog No. M26207 CAS No. 1072145-33-5

ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1.ERRα antagonist-1 is a selective and high affinity estrogen-related receptor α (ERRα) antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ERRα antagonist-1
  • Note
    Research use only, not for human use.
  • Brief Description
    ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1.ERRα antagonist-1 is a selective and high affinity estrogen-related receptor α (ERRα) antagonist.
  • Description
    ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1.ERRα antagonist-1 is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ERR+/- antagonist-1 | ERRa antagonist-1
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1072145-33-5
  • Formula Weight
    377.52
  • Molecular Formula
    C21H19N3S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (66.22 mM)
  • SMILES
    C1CN=C(S1)N1CCS\C1=N/C1c2ccccc2C=Cc2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Shi S, Liu Y, Wu J, Li Z, Zhao Y, Zhong D, Zeng F. Comparative bioavailability and tolerability of a single 20-mg dose of two fluoxetine hydrochloride dispersible tablet formulations in fasting, healthy Chinese male volunteers:an open-label, randomized-sequence, two-period crossover study. Clin Ther. 2010 Oct;32(11):1977-86.
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